Recent publications

You can find all publication on google scholar

First/Co-first author

• Monopogen: single nucleotide variant calling from single cell sequencing.
  J Dou, Y Tan, KH Kock, J Wang , X Cheng, LM Tan, KY Han, CC Hon, WY Park, JW Shin, H Jin, H Chen, L Ding, S Prabhakar, N Navin. K Chen. Nature Biotechnology 2023.
  see Research Highlight in Nature Genetics.

• Large-scale whole-genome sequencing of three diverse Asian populations in Singapore.
  D Wu*, J Dou*, X Chai*, C Bellis, A Wilm, C.C. Shih, W.W.J Soon, N Bertin, C.B Lin, C.C Khor, M DeGiorgio, S.S Cheng, L Bao, N Karnani, W Hwang, S Davila, P Tan, A Shabbir, A Moh, E Tan, J.N Foo, L.L Goh, K.P Leong, R.S.Y Foo, C Lam, A Richards, C.Y Cheng, T Aung, T Wong, H Ng, M Ackers-Johnson, E Aliwarga, K Kim Ban, D Bertrand, J Chambers, D Hui Chan, C Li Chan, M Chee, M Chee, P Chen, Y Chen, E Chew, W Chew, L Chiam, J Chong, I Chua, S Cook, W Dai, R Dorajoo, C Foo, R Goh, A Hillmer, I Irwan, F Jaufeerally, A Javed, J Jeyakani, J Koh, J Koh, P Krishnaswamy, J Kuan, N Kumari, A Lee, S Lee, S Lee, Y Lee, S Leong, Z Li, P Li, J Liew, O Liew, S Lim, W Lim, C Lim, T Lim, C Lim, S Loh, A Lok, C Chin, S Majithia, S Maurer-Stroh, W Meah, S Mok, N Nargarajan, P Ng, S Ng, Z Ng, J Ng, E Ng, S Ng, S Nusinovici, C Ong, B Pan, V Pedergnana, S Poh, S Prabhakar, K Prakash, I Quek, C Sabanayagam, W See, Y Sia, X Sim, W Sim, J So, D Soon, E Tai, N Tan, L Tan, H Tan, W Tan, M Tandiono, A Tay, S Thakur, Y Tham, Z Tiang, G Toh, P Tsai, L Veeravalli, C Verma, L Wang, M Wang, W Wong, Z Xie, K Yeo, L Zhang, W Zhai, Y Zhao, J Liu, C Wang. Cell 2019 (Cover story)

• Metabolic competition is an important driver of tumor resistance after CAR NK cell therapy and can be overcome by cytokine engineering.
  L Li*, V Mohanty*, J Dou*, Y Huang*, P P. Banerjee, Q Miao, J Lohr, T Vijaykumar, B Knoechel, R Basar, S Liang, M Kaplan, M Daher, E Liu, L Muniz-Feliciano, T J. Laskowski, D Marin, S Mielke, R E. C, Elizabeth J. Shpall, K Chen, K Rezvani. Science Advance 2023

• Bi-order multimodal integration of single-cell data.
  J Dou*, S Liang*, V Mohanty, X Cheng, S Kim, J Choi, Y Li, K Rezvani, R Chen, K Chen. Genome Biology 2022

• Using off-target data from whole-exome sequencing to improve genotyping accuracy, association analysis, and polygenic risk prediction.
  J Dou*, D Wu*, L Ding, K Wang, M Jiang, X Chai, D. Reilly, E Tai, J Liu, X Sim, S Cheng, C Wang. Brief in Bioinformatics 2020

• Estimation of kinship coefficient in structured and admixed populations using sparse sequencing data.
  J Dou, B Sun, X Sim, I Irwan, J D Hughes, D F Reilly, E Tai, J Liu, C Wang. PLoS Genetics 2017

• Whole-genome restriction mapping by “subhaploid”-based RAD sequencing: an efficient and flexible approach for physical mapping and genome scaffolding.
  J Dou, H Dou, C Mu, L Zhang, Y Li, J, T Li, X Hu, S Wang, Z Bao. Genetics 2017 (Cover story)

• Evaluation of the 2b-RAD method for genomic selection in scallop breeding.
  J Dou, X Li, Q Fu, W Jiao, Y Li, T Li, Y Wang, X Hu, S Wang, Z Bao. Scientific Report 2016

• High-resolution linkage and quantitative trait locus mapping aided by genome survey sequencing: building up an integrative genomic framework for a bivalve mollusc.
  W Jiao*, X Fu*, J Dou*, H Li, H Su, J Mao, Q Yu, L Zhang, X Hu, X Huang, Y Wang, S Wang, Z Bao. DNA Research 2013 (Editor’s choice)

• RADtyping: an integrated package for accurate de novo codominant and dominant RAD genotyping in mapping populations.
  X Fu*, J Dou*, J Mao, H Su, W Jiao, L Zhang, X Hu, X Huang, S Wang, Z Bao. PLoS ONE 2013

• Reference-free SNP calling: improved accuracy by preventing incorrect calls from repetitive genomic regions.
  J Dou, X Zhao, X Fu, W Jiao, N Wang, L Zhang, X Hu, S Wang, Z Bao. Biology Direct 2012

Contributing author (selected)

• Cord blood characteristics determine the efficacy of allogeneic IL-15 armored CAR-transduced natural killer cells against CD19-positive B cell tumors.
  D Marin*, Y Li*, R Basar*, H Rafei*, M Daher*, J Dou, V Mohanty, M Dede, Y Nieto,N Uprety,S Acharya,E Liu ,J Wilson, P Banerjee, H Macapinlac, C Ganesh, P Thall, R Bassett, M Ammari, S Rao, Cao,M Shanley, C Hosing,P Kebriaei, L Nastoupil, C Flowers, S Moseley,P Lin, S Ang, U Popat, M Qazilbash,R Champlin, K Chen, E Shpall, K Rezvani. Nature Medicine 2023

• KLF5 governs sphingolipid metabolism and barrier function of the skin.
  Y Lyu, Y Guan, L Deliu, E Humphrey, J Frontera, Y Yang, J Dou,…,K Chen,P Nagarajan, Y Ge. Genes Development 2022

• Systematic decomposition of sequence determinants governing CRISPR/Cas9 specificity.
  R Fu*, W He*, J Dou, O D. Villarreal, E Bedford, H Wang, C Hou, L Zhang, Y Wang, Y Chen, X Gao, M Depken, H Xu. Nature Communications 2022

• Single-cell manifold-preserving feature selection for detecting rare cell populations.
  S Liang, V Mohanty, J Dou, Q Miao, Y Huang, M Muftuoglu, L Ding, W Peng, K Chen. Nature Computational Science 2021

• Single-cell copy number lineage tracing enabling gene discovery.
  F Wang, Q Wang, V Mohanty, S Liang, J Dou, J Han, D Conterno Minussi, R Gao, L Ding, N Navin, K Chen. Genome Biology 2021

• Genetic Admixture in the Culturally Unique Peranakan Chinese Population in Southeast Asia.
  D Wu, P Li, B Pan, Z Tiang, J Dou, I Williantarra, A Pribowo, R Nurdiansyah, SG Peranakan Project, R SY Foo, C Wang. Molecular Biology and Evolution 2021

• Generation of glucocorticoid-resistant SARS-CoV-2 T cells for adoptive cell therapy.
  R Basar, N Uprety, E Ensley, M Daher, K Klein,…,J Dou,..,K Rezvani. Cell Report 2021

• Targeting the v integrin-TGF-beta axis improves natural killer cell function against glioblastoma stem cells.
  H Shaim, M Shanley, R Basar, M Daher,…, J Dou,…,K Chen, F Lang, E Shpall, A Heimberger, K Rezvan. The Journal of Clinical Investigation 2021

• De novo identification of essential protein domains from CRISPR-Cas9 tiling-sgRNA knockout screens.
  W He, L Zhang, O Villarreal, R Fu, E Bedford, J Dou, A Patel, M Bedford, X Shi, T Chen, B Bartholomew, H Xu. Nature Communications 2019

• Scallop genome reveals molecular adaptations to semi-sessile life and neurotoxins.
  Y Li, X Sun, X Hu, X Xun, J Zhang, X Guo,…, J Dou,…, Z Jiang, R Li, S Wang, Z Bao. Nature Communications 2017

• Scallop genome provides insights into evolution of bilaterian karyotype and development.
  S Wang, J Zhang, W Jiao, J Li, X Xun, Y Sun,…,J Dou,…, Z Jiang, D Chourrout, R Li, Z Bao. Nature Ecology and Evolution 2017

* denotes equal contributions, ^# corresponding authors